Engineering a genetically-encoded SHG chromophore by electrostatic targeting to the membrane

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Engineering a genetically-encoded SHG chromophore by electrostatic targeting to the membrane

Although second harmonic generation (SHG) microscopy provides unique imaging advantages for voltage imaging and other biological applications, genetically-encoded SHG chromophores remain relatively unexplored. SHG only arises from non-centrosymmetric media, so an anisotropic arrangement of chromophores is essential to provide strong SHG signals. Here, inspired by the mechanism by which K-Ras4B ...

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ژورنال

عنوان ژورنال: Frontiers in Molecular Neuroscience

سال: 2014

ISSN: 1662-5099

DOI: 10.3389/fnmol.2014.00093